The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Fluoro-2-methylpyrimidin-4-amine, is researched, Molecular C5H6FN3, CAS is 1416372-67-2, about Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt, the main research direction is amino fluoropyrimidine preparation; amidine hydrochloride potassium cyano fluoroethenolate cyclization; fluoropyrazole amino preparation; hydrazine potassium cyano fluoroethenolate cyclization; cyclization; fluorinated heterocycles; fluorine; pyrazoles; pyrimidines.Application of 1416372-67-2.
A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
Different reactions of this compound(5-Fluoro-2-methylpyrimidin-4-amine)Application of 1416372-67-2 require different conditions, so the reaction conditions are very important.
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics