Month: August 2024

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride(SMILESS: O=C1CNNC2=C1C=CC=C2.[H]Cl,cas:137195-33-6) is researched.Computed Properties of C26H23BF4O4. The article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》 in relation to this compound, is published in Pharmazie. Let’s take a look at the latest research on this compound (cas:137195-33-6).

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

Different reactions of this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Application of 137195-33-6 require different conditions, so the reaction conditions are very important.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt, published in 2020, which mentions a compound: 1416372-67-2, Name is 5-Fluoro-2-methylpyrimidin-4-amine, Molecular C5H6FN3, Safety of 5-Fluoro-2-methylpyrimidin-4-amine.

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

After consulting a lot of data, we found that this compound(1416372-67-2)Safety of 5-Fluoro-2-methylpyrimidin-4-amine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics