Application In Synthesis of 5-Fluoro-2-methylpyrimidin-4-amine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Fluoro-2-methylpyrimidin-4-amine, is researched, Molecular C5H6FN3, CAS is 1416372-67-2, about Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt.
A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
After consulting a lot of data, we found that this compound(1416372-67-2)Application In Synthesis of 5-Fluoro-2-methylpyrimidin-4-amine can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics