The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ) is researched.Application of 137195-33-6.Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. published the article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》 about this compound( cas:137195-33-6 ) in Pharmazie. Keywords: central nervous system cinnoline derivative preparation. Let’s learn more about this compound (cas:137195-33-6).
Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.
This compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Application of 137195-33-6 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics