Application of 1416372-67-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoro-2-methylpyrimidin-4-amine, is researched, Molecular C5H6FN3, CAS is 1416372-67-2, about Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt. Author is Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till.
A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
This compound(5-Fluoro-2-methylpyrimidin-4-amine)Application of 1416372-67-2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics