Month: April 2022

Category: cinnoline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides. Author is Groszkowski, Stefan; Stanczak, Andrzej.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

In some applications, this compound(137195-33-6)Category: cinnoline is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Acta Poloniae Pharmaceutica called Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline, Author is Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan, which mentions a compound: 137195-33-6, SMILESS is O=C1CNNC2=C1C=CC=C2.[H]Cl, Molecular C8H9ClN2O, Related Products of 137195-33-6.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

In some applications, this compound(137195-33-6)Related Products of 137195-33-6 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan published an article about the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6,SMILESS:O=C1CNNC2=C1C=CC=C2.[H]Cl ).COA of Formula: C8H9ClN2O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:137195-33-6) through the article.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

In some applications, this compound(137195-33-6)COA of Formula: C8H9ClN2O is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan published an article about the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6,SMILESS:O=C1CNNC2=C1C=CC=C2.[H]Cl ).Name: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:137195-33-6) through the article.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives.Reference of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till published an article about the compound: 5-Fluoro-2-methylpyrimidin-4-amine( cas:1416372-67-2,SMILESS:NC1=NC(C)=NC=C1F ).Computed Properties of C5H6FN3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1416372-67-2) through the article.

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. published the article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》. Keywords: central nervous system cinnoline derivative preparation.They researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Formula: C8H9ClN2O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:137195-33-6) here.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives, published in 1994-06-30, which mentions a compound: 137195-33-6, mainly applied to central nervous system cinnoline derivative preparation, Category: cinnoline.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride.They published the article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》 about this compound( cas:137195-33-6 ) in Pharmazie. Keywords: central nervous system cinnoline derivative preparation. We’ll tell you more about this compound (cas:137195-33-6).

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

As far as I know, this compound(137195-33-6)Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan published the article 《Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline》. Keywords: cinnolone tetrahydro haloacyl derivative.They researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:137195-33-6) here.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

As far as I know, this compound(137195-33-6)Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics