Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1416372-67-2, is researched, Molecular C5H6FN3, about Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt, the main research direction is amino fluoropyrimidine preparation; amidine hydrochloride potassium cyano fluoroethenolate cyclization; fluoropyrazole amino preparation; hydrazine potassium cyano fluoroethenolate cyclization; cyclization; fluorinated heterocycles; fluorine; pyrazoles; pyrimidines.Safety of 5-Fluoro-2-methylpyrimidin-4-amine.
A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics