So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride.They published the article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》 about this compound( cas:137195-33-6 ) in Pharmazie. Keywords: central nervous system cinnoline derivative preparation. We’ll tell you more about this compound (cas:137195-33-6).
Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.
As far as I know, this compound(137195-33-6)Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics