The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ) is researched.Application of 137195-33-6.Groszkowski, Stefan; Stanczak, Andrzej published the article 《Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides》 about this compound( cas:137195-33-6 ) in Acta Poloniae Pharmaceutica. Keywords: oxotetrahydrocinnoline hydrochloride; cinnoline oxotetrahydro. Let’s learn more about this compound (cas:137195-33-6).
The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.
As far as I know, this compound(137195-33-6)Application of 137195-33-6 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics