Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 137195-33-6, is researched, SMILESS is O=C1CNNC2=C1C=CC=C2.[H]Cl, Molecular C8H9ClN2OJournal, Article, Pharmazie called Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives, Author is Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W., the main research direction is central nervous system cinnoline derivative preparation.Application of 137195-33-6.
Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.
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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics