Month: March 2022

Computed Properties of C8H9ClN2O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides. Author is Groszkowski, Stefan; Stanczak, Andrzej.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

If you want to learn more about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Computed Properties of C8H9ClN2O, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. published an article about the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6,SMILESS:O=C1CNNC2=C1C=CC=C2.[H]Cl ).Reference of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:137195-33-6) through the article.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

If you want to learn more about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Reference of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till published an article about the compound: 5-Fluoro-2-methylpyrimidin-4-amine( cas:1416372-67-2,SMILESS:NC1=NC(C)=NC=C1F ).Quality Control of 5-Fluoro-2-methylpyrimidin-4-amine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1416372-67-2) through the article.

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

If you want to learn more about this compound(5-Fluoro-2-methylpyrimidin-4-amine)Quality Control of 5-Fluoro-2-methylpyrimidin-4-amine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1416372-67-2).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Groszkowski, Stefan; Stanczak, Andrzej published the article 《Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides》. Keywords: oxotetrahydrocinnoline hydrochloride; cinnoline oxotetrahydro.They researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Name: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:137195-33-6) here.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

Here is a brief introduction to this compound(137195-33-6)Name: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, if you want to know about other compounds related to this compound(137195-33-6), you can read my other articles.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 137195-33-6, is researched, Molecular C8H9ClN2O, about Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives, the main research direction is central nervous system cinnoline derivative preparation.Application of 137195-33-6.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

Here is a brief introduction to this compound(137195-33-6)Application of 137195-33-6, if you want to know about other compounds related to this compound(137195-33-6), you can read my other articles.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics