The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride(SMILESS: O=C1CNNC2=C1C=CC=C2.[H]Cl,cas:137195-33-6) is researched.Electric Literature of C8H12ClNO2. The article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》 in relation to this compound, is published in Pharmazie. Let’s take a look at the latest research on this compound (cas:137195-33-6).
Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.
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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics