Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1416372-67-2, is researched, SMILESS is NC1=NC(C)=NC=C1F, Molecular C5H6FN3Journal, Article, Beilstein Journal of Organic Chemistry called Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt, Author is Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till, the main research direction is amino fluoropyrimidine preparation; amidine hydrochloride potassium cyano fluoroethenolate cyclization; fluoropyrazole amino preparation; hydrazine potassium cyano fluoroethenolate cyclization; cyclization; fluorinated heterocycles; fluorine; pyrazoles; pyrimidines.Application of 1416372-67-2.
A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
In addition to the literature in the link below, there is a lot of literature about this compound(5-Fluoro-2-methylpyrimidin-4-amine)Application of 1416372-67-2, illustrating the importance and wide applicability of this compound(1416372-67-2).
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics