The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Fluoro-2-methylpyrimidin-4-amine( cas:1416372-67-2 ) is researched.Quality Control of 5-Fluoro-2-methylpyrimidin-4-amine.Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till published the article 《Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt》 about this compound( cas:1416372-67-2 ) in Beilstein Journal of Organic Chemistry. Keywords: amino fluoropyrimidine preparation; amidine hydrochloride potassium cyano fluoroethenolate cyclization; fluoropyrazole amino preparation; hydrazine potassium cyano fluoroethenolate cyclization; cyclization; fluorinated heterocycles; fluorine; pyrazoles; pyrimidines. Let’s learn more about this compound (cas:1416372-67-2).
A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics