So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Groszkowski, Stefan; Stanczak, Andrzej researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Electric Literature of C8H9ClN2O.They published the article 《Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides》 about this compound( cas:137195-33-6 ) in Acta Poloniae Pharmaceutica. Keywords: oxotetrahydrocinnoline hydrochloride; cinnoline oxotetrahydro. We’ll tell you more about this compound (cas:137195-33-6).
The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.
Compound(137195-33-6)Electric Literature of C8H9ClN2O received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride), if you are interested, you can check out my other related articles.
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics