Formula: C5H6FN3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Fluoro-2-methylpyrimidin-4-amine, is researched, Molecular C5H6FN3, CAS is 1416372-67-2, about Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt. Author is Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till.
A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
There is still a lot of research devoted to this compound(SMILES：NC1=NC(C)=NC=C1F)Formula: C5H6FN3, and with the development of science, more effects of this compound(1416372-67-2) can be discovered.
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics