So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till researched the compound: 5-Fluoro-2-methylpyrimidin-4-amine( cas:1416372-67-2 ).Safety of 5-Fluoro-2-methylpyrimidin-4-amine.They published the article 《Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt》 about this compound( cas:1416372-67-2 ) in Beilstein Journal of Organic Chemistry. Keywords: amino fluoropyrimidine preparation; amidine hydrochloride potassium cyano fluoroethenolate cyclization; fluoropyrazole amino preparation; hydrazine potassium cyano fluoroethenolate cyclization; cyclization; fluorinated heterocycles; fluorine; pyrazoles; pyrimidines. We’ll tell you more about this compound (cas:1416372-67-2).
A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
If you want to learn more about this compound(5-Fluoro-2-methylpyrimidin-4-amine)Safety of 5-Fluoro-2-methylpyrimidin-4-amine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1416372-67-2).
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics