Day: March 30, 2022

Quality Control of 5-Fluoro-2-methylpyrimidin-4-amine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Fluoro-2-methylpyrimidin-4-amine, is researched, Molecular C5H6FN3, CAS is 1416372-67-2, about Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt. Author is Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till.

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

Compound(1416372-67-2)Quality Control of 5-Fluoro-2-methylpyrimidin-4-amine received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoro-2-methylpyrimidin-4-amine), if you are interested, you can check out my other related articles.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Groszkowski, Stefan; Stanczak, Andrzej researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Electric Literature of C8H9ClN2O.They published the article 《Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides》 about this compound( cas:137195-33-6 ) in Acta Poloniae Pharmaceutica. Keywords: oxotetrahydrocinnoline hydrochloride; cinnoline oxotetrahydro. We’ll tell you more about this compound (cas:137195-33-6).

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

Compound(137195-33-6)Electric Literature of C8H9ClN2O received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride), if you are interested, you can check out my other related articles.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. published the article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》. Keywords: central nervous system cinnoline derivative preparation.They researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:137195-33-6) here.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

Compound(137195-33-6)Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride), if you are interested, you can check out my other related articles.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till published an article about the compound: 5-Fluoro-2-methylpyrimidin-4-amine( cas:1416372-67-2,SMILESS:NC1=NC(C)=NC=C1F ).Application of 1416372-67-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1416372-67-2) through the article.

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

From this literature《Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt》,we know some information about this compound(1416372-67-2)Application of 1416372-67-2, but this is not all information, there are many literatures related to this compound(1416372-67-2).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ) is researched.Recommanded Product: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride.Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. published the article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》 about this compound( cas:137195-33-6 ) in Pharmazie. Keywords: central nervous system cinnoline derivative preparation. Let’s learn more about this compound (cas:137195-33-6).

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

From this literature《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》,we know some information about this compound(137195-33-6)Recommanded Product: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, but this is not all information, there are many literatures related to this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

HPLC of Formula: 137195-33-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides. Author is Groszkowski, Stefan; Stanczak, Andrzej.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

From this literature《Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides》,we know some information about this compound(137195-33-6)HPLC of Formula: 137195-33-6, but this is not all information, there are many literatures related to this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Name: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

From this literature《Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline》,we know some information about this compound(137195-33-6)Name: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, but this is not all information, there are many literatures related to this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Computed Properties of C5H6FN3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoro-2-methylpyrimidin-4-amine, is researched, Molecular C5H6FN3, CAS is 1416372-67-2, about Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt. Author is Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till.

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

From this literature《Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt》,we know some information about this compound(1416372-67-2)Computed Properties of C5H6FN3, but this is not all information, there are many literatures related to this compound(1416372-67-2).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Formula: C5H6FN3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Fluoro-2-methylpyrimidin-4-amine, is researched, Molecular C5H6FN3, CAS is 1416372-67-2, about Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt. Author is Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till.

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

There is still a lot of research devoted to this compound(SMILES：NC1=NC(C)=NC=C1F)Formula: C5H6FN3, and with the development of science, more effects of this compound(1416372-67-2) can be discovered.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt, published in 2020, which mentions a compound: 1416372-67-2, Name is 5-Fluoro-2-methylpyrimidin-4-amine, Molecular C5H6FN3, Recommanded Product: 5-Fluoro-2-methylpyrimidin-4-amine.

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

There is still a lot of research devoted to this compound(SMILES：NC1=NC(C)=NC=C1F)Recommanded Product: 5-Fluoro-2-methylpyrimidin-4-amine, and with the development of science, more effects of this compound(1416372-67-2) can be discovered.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics