Month: March 2022

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1416372-67-2, is researched, SMILESS is NC1=NC(C)=NC=C1F, Molecular C5H6FN3Journal, Article, Beilstein Journal of Organic Chemistry called Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt, Author is Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till, the main research direction is amino fluoropyrimidine preparation; amidine hydrochloride potassium cyano fluoroethenolate cyclization; fluoropyrazole amino preparation; hydrazine potassium cyano fluoroethenolate cyclization; cyclization; fluorinated heterocycles; fluorine; pyrazoles; pyrimidines.Application of 1416372-67-2.

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Category: cinnoline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline. Author is Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives, published in 1994-06-30, which mentions a compound: 137195-33-6, Name is 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, Molecular C8H9ClN2O, Synthetic Route of C8H9ClN2O.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives, the main research direction is central nervous system cinnoline derivative preparation.Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

There are many compounds similar to this compound(137195-33-6)Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Groszkowski, Stefan; Stanczak, Andrzej published an article about the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6,SMILESS:O=C1CNNC2=C1C=CC=C2.[H]Cl ).COA of Formula: C8H9ClN2O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:137195-33-6) through the article.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

There are many compounds similar to this compound(137195-33-6)COA of Formula: C8H9ClN2O. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Fluoro-2-methylpyrimidin-4-amine( cas:1416372-67-2 ) is researched.Quality Control of 5-Fluoro-2-methylpyrimidin-4-amine.Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till published the article 《Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt》 about this compound( cas:1416372-67-2 ) in Beilstein Journal of Organic Chemistry. Keywords: amino fluoropyrimidine preparation; amidine hydrochloride potassium cyano fluoroethenolate cyclization; fluoropyrazole amino preparation; hydrazine potassium cyano fluoroethenolate cyclization; cyclization; fluorinated heterocycles; fluorine; pyrazoles; pyrimidines. Let’s learn more about this compound (cas:1416372-67-2).

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

There are many compounds similar to this compound(1416372-67-2)Quality Control of 5-Fluoro-2-methylpyrimidin-4-amine. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Acta Poloniae Pharmaceutica called Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides, Author is Groszkowski, Stefan; Stanczak, Andrzej, which mentions a compound: 137195-33-6, SMILESS is O=C1CNNC2=C1C=CC=C2.[H]Cl, Molecular C8H9ClN2O, Related Products of 137195-33-6.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

I hope my short article helps more people learn about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Related Products of 137195-33-6. Apart from the compound(137195-33-6), you can read my other articles to know other related compounds.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Computed Properties of C8H9ClN2O.They published the article 《Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline》 about this compound( cas:137195-33-6 ) in Acta Poloniae Pharmaceutica. Keywords: cinnolone tetrahydro haloacyl derivative. We’ll tell you more about this compound (cas:137195-33-6).

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

I hope my short article helps more people learn about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Computed Properties of C8H9ClN2O. Apart from the compound(137195-33-6), you can read my other articles to know other related compounds.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Acta Poloniae Pharmaceutica called Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline, Author is Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan, which mentions a compound: 137195-33-6, SMILESS is O=C1CNNC2=C1C=CC=C2.[H]Cl, Molecular C8H9ClN2O, Quality Control of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

I hope my short article helps more people learn about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Quality Control of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. Apart from the compound(137195-33-6), you can read my other articles to know other related compounds.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Application In Synthesis of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives. Author is Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W..

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics