Reference of 875-66-1, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Reference of 875-66-1, Name is Cinnolin-4-ol, molecular formula is C8H6N2O. In a Article, authors is Naik, Maruti£¬once mentioned of Reference of 875-66-1
4-Aminoquinolone piperidine amides: Noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity
4-Aminoquinolone piperidine amides (AQs) were identified as a novel scaffold starting from a whole cell screen, with potent cidality on Mycobacterium tuberculosis (Mtb). Evaluation of the minimum inhibitory concentrations, followed by whole genome sequencing of mutants raised against AQs, identified decaprenylphosphoryl-beta-d-ribose 2?-epimerase (DprE1) as the primary target responsible for the antitubercular activity. Mass spectrometry and enzyme kinetic studies indicated that AQs are noncovalent, reversible inhibitors of DprE1 with slow on rates and long residence times of ?100 min on the enzyme. In general, AQs have excellent leadlike properties and good in vitro secondary pharmacology profile. Although the scaffold started off as a single active compound with moderate potency from the whole cell screen, structure-activity relationship optimization of the scaffold led to compounds with potent DprE1 inhibition (IC50 < 10 nM) along with potent cellular activity (MIC = 60 nM) against Mtb. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Reference of 875-66-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about Reference of 875-66-1, in my other articles.
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Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics